Liquid-free ionic conductive elastomers with high mechanical properties and ionic conductivity for multifunctional sensors and triboelectric nanogenerators.

Liquid-free ionic conductive elastomers (ICEs) are ideal materials for constructing flexible electronic devices by avoiding the limitations of liquid components. However, developing all-solid-state ionic conductors with high mechanical strength, high ionic conductivity, excellent healing, and recyclability remains a great challenge. Herein, a series of liquid-free polyurethane-based ICEs with a double dynamic crosslinked structure are reported. As a result of interactions between multiple dynamic bonds (multi-level hydrogen bonds, disulfide bonds, and dynamic D-A bonds) and lithium-oxygen bonds, the optimal ICE exhibited a high mechanical strength (1.18 MPa), excellent ionic conductivity (0.14 mS cm-1), desirable healing capacity (healing efficiency >95%), and recyclability. A multi-functional wearable sensor based on the novel ICE enabled real-time and rapid detection of various human activities and enabled recognizing writing signals and encrypted information transmission. A triboelectric nanogenerator based on the novel ICE exhibited an excellent open-circuit voltage of 464 V, a short-circuit current of 16 µA, a transferred charge of 50 nC, and a power density of 720 mW m-2, enabling powering of small-scale electronic products. This study provides a feasible strategy for designing flexible sensor products and healing, self-powered devices, with promising prospects for application in soft ionic electronics.

Optimization of composting methods for efficient use of cassava waste, using microbial degradation.

With the recent revolution in the green economy, agricultural solid waste resource utilization has become an important project. A small-scale laboratory orthogonal experiment was set up to investigate the effects of C/N ratio, initial moisture content and fill ratio (vcassava residue: vgravel) on the maturity of cassava residue compost by adding Bacillus subtilis and Azotobacter chroococcum. The highest temperature in the thermophilic phase of the low C/N ratio treatment is significantly lower than the medium and high C/N ratios. The C/N ratio and moisture content have a significant impact on the results of cassava residue composting, while the filling ratio only has a significant impact on the pH value and phosphorus content. Based on comprehensive analysis, the recommended process parameters for pure cassava residue composting are a C/N ratio of 25, an initial moisture content of 60%, and a filling ratio of 5. Under these conditions, the high-temperature conditions can be reached and maintained quickly, the organic matter has been degraded by 36.1%, the pH value has dropped to 7.36, the E4/E6 ratio is 1.61, the conductivity value has dropped to 2.52 mS/cm, and the final germination index increased to 88%. The thermogravimetry, scanning electron microscope, and energy spectrum analysis also showed that the cassava residue was effectively biodegraded. Cassava residue composting with this process parameter has great reference significance for the actual production and application of agriculture.

Effect of Health Education Based on Integrative Therapy of Chinese and Western Medicine for Adult Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Study.

OBJECTIVE: To investigate the effects of health education based on integrative therapy of Chinese and Western medicine for type 2 diabetes mellitus (T2DM) from the aspects of knowledge, attitude and practice (KAP), health-related quality of life (HRQoL), body mass index (BMI) and glucose control. METHODS: Patients were individually randomized into intervention group (receiving integrative education, n=120) and control group (receiving usual education, n=120). The primary outcome was the changes in glycosylated hemoglobin A1c (HbA1c) levels after 3, 6, 9 and 12 months from baseline. Hierarchical linear models (HLMs) were used to assess within-group changes in outcomes over time and between-group differences in patterns of change. Secondary outcomes were KAP scores, HRQoL scores and BMI after 6 and 12 months, paired-sample t test was used to assess within-group changes in outcomes in 6 and 12 months, independent-sample t test was used to assess between-group differences in patterns of change. RESULTS: HbA1c decreased statistically from baseline to 3 months, from 3 to 6 months, from 6 to 9 months and from 9 to 12 months in the intervention group (all P<0.01); and decreased significantly from baseline to 3 months, and from 3 to 6 months in the control group P<0.01). There was a significant between-group difference from baseline to 3 months (P=0.044), from 6 to 9 months (P<0.01) and from 9 to 12 months (P<0.01). Significant improvements in the intervention group along with significant between-group differences were found in KAP and HRQoL scores respectively (all P<0.05). The number in the intervention group of normal weight increased from 56 at baseline to 81 (6 months), 94 (12 months), the number in the control group were 63 (baseline), 69 (6 months), 70 (12 months), the χ2 of hierarchical analysis of BMI were 6.93 (P=0.075), 10.31 (P=0.016), 15.53 (P<0.01), respectively. CONCLUSION: Health education based on integrative therapy of Chinese and Western medicine is beneficial to the control of T2DM and should be recommended for T2DM.

Effectiveness of family involvement in newly diagnosed type 2 diabetes patients: a follow-up study.

OBJECTIVE: To investigate the effects of family-involvement on health education for T2DM from the aspects of knowledge, attitude and practice (KAP), health-related quality of life (HRQoL), body mass index (BMI) and glucose control. METHODS: A follow-up study was performed and patients with newly diagnosed T2DM were divided into family-involved group (FIG, n=60) and single-involved group (SIG, n=60). Hierarchical linear models were used to assess within-group changes and between-group differences in the glycosylated hemoglobin A1c (HbA1c), KAP, SF-36 and BMI. RESULTS: Significant improvements in FIG along with significant differences between-group were seen for HbA1c levels (9.73, 8.92, 5.55, 5.79, 5.30 vs. 10.05, 9.53, 6.36, 8.41, 6.58) in baseline, M3, M6, M12, M24 compared with SIG, respectively (all P≤0.001). Significant improvements in FIG along with significant differences between-group were seen for KAP (16.23, 46.98, 48.93 vs. 16.65, 29.07, 37.62), SF-36 (78.04, 92.68, 92.34 vs. 74.96, 77.03, 78.25), and BMI (24.74, 23.46, 22.96 vs. 24.00, 23.45, 23.50) in baseline, M12 and M24, respectively (all P≤0.05). CONCLUSION: Family involvement is beneficial to the control of T2DM and should be suggested for T2DM newly diagnosed. PRACTICE IMPLICATIONS: Health education should encourage the family to participate in the whole process to improve the efficacy of education.

Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes.

Previous studies have indicated that the early steps in the isoprenoid/cholesterol biosynthetic pathway occur in peroxisomes. However, the role of peroxisomes in cholesterol biosynthesis has recently been questioned in several reports concluding that three of the peroxisomal cholesterol biosynthetic enzymes, namely mevalonate kinase, phosphomevalonate kinase, and mevalonate diphosphate decarboxylase, do not localize to peroxisomes in human cells even though they contain consensus peroxisomal targeting signals. We re-investigated the subcellular localization of the cholesterol biosynthetic enzymes of the pre-squalene segment in human cells by using new stable isotopic techniques and data computations with isotopomer spectral analysis, in combination with immunofluorescence and cell permeabilization techniques. Our present findings clearly show and confirm previous studies that the pre-squalene segment of the cholesterol biosynthetic pathway is localized to peroxisomes. In addition, our data are consistent with the hypothesis that acetyl-CoA derived from peroxisomal beta-oxidation of very long-chain fatty acids and medium-chain dicarboxylic acids is preferentially channeled to cholesterol synthesis inside the peroxisomes without mixing with the cytosolic acetyl-CoA pool.

The effect of sterol regulatory element-binding protein 2 polymorphism on the serum lipid in northern Chinese subjects.

Sterol regulatory element-binding protein 2 (SREBP-2) is an important nuclear transcription factor in the regulation of cellular cholesterol metabolism. To determine allele frequency of the 1784G>C polymorphism at the SREBP-2 locus and investigate the relationship between this polymorphism and serum lipid levels in Chinese people, we selected 486 individuals (118 men and 368 women) from the Xicheng District of Beijing. The subjects were divided into four groups: hypercholesterolemic subjects, hypertriglyceridemic subjects, combined hyperlipidemic subjects, and normal subjects. Serum lipid profiles were measured in all subjects, and 1784G>C was analyzed using polymerase chain reaction-restriction fragment length polymorphism analysis. There was no significant difference in genotype frequencies or allele frequencies of this polymorphism between the hyperlipidemic and control groups. The serum total cholesterol (TC) and LDL cholesterol (LDL-C) levels of the individuals carrying the C allele were higher than the noncarriers in both males and females in the hypercholesterolemic group, but statistical significance was only observed in females. The results of this study indicate that the SREBP-2 polymorphism is related to elevated concentrations of serum TC and LDL-C in hypercholesterolemic subjects. Further work is necessary to confirm the role of 1784G>C in the development of hyperlipidemia.

[Relations between polymorphism of sterol regulatory element binding protein-2 gene and hyperlipidemia in the Han ethics of China].

OBJECTIVE: To determine allele frequencies of 1784G > C polymorphism in Sterol Regulatory Element Binding Protein-2 (SREBP-2) gene and investigate the relationship between this polymorphism and serum lipid levels in hyperlipidemic and normolipidemic individuals residing in Beijing City, China. METHODS: A total of 322 unrelated hyperlipidemic individuals and 164 unrelated normolipidemic individuals were selected from Xicheng District of Beijing. For all subjects the serum lipids profiles were measured and the 1784G > C polymorphism was analyzed (PCR-RFLP). RESULTS: The frequencies of C allele in hyperlipidemic and control groups were 0.196 and 0.201, respectively. There was no significant difference in genotype frequencies or allele frequencies of this polymorphism between hyperlipidemic and control groups. When the hyperlipidemic subjects were divided into three subgroups according to lipid levels, it was shown that the serum TC and LDL-C levels of the individuals carrying C allele were significantly higher than the non-carriers in the hypercholesterolemic subgroup. There were no statistically significant differences for any of these parameters across genotypes in hypertriglyceridemic, combined hyperlipidemic and normolipidemic groups. CONCLUSION: The study indicated that 1784GC/CC genotypes of SREBP-2 were significantly related with the elevated concentrations of serum TC and LDL-C in hypercholesterolemic subjects, and further work is necessary to confirm the role of 1784G > C polymorphism of SREBP-2 gene in the development of hyperlipidemia.

[Relationship between the patients' knowledge on hypertension prevention and control and the rate on blood pressure control].

OBJECTIVE: To study the relationship between blood pressure control status and patients' knowledge on hypertension prevention and control among hypertensive patients. METHODS: A total of 726 hypertensives were selected from four community health service centers (2 urban and 2 rural) in Beijing. All subjects were investigated by questionnaires and their blood pressures were measured at the same time. RESULTS: The rate for blood pressure under control (< 140/90 mm Hg, 1 mm Hg = 0.133 kPa) in the rural and urban patients were 46.4% and 23.9% respectively. The control rate increased with the increase of patients' knowledge on prevention and control of hypertension in both urban and rural patients. The cumulative effect of knowledge on hypertension control status could contribute 30.0% to the difference in hypertension control rate between rural and urban patients. CONCLUSION: Patients' knowledge on hypertension control was significantly related to the rate on hypertension control. Health education should be helpful to improve the rate on hypertension control.